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Lucia Taja-Chayeb Selected Research

Hydralazine (Apresoline)

10/2014Hydralazine-valproate: a repositioned drug combination for the epigenetic therapy of cancer.
6/2012Epigenetic therapy with hydralazine and magnesium valproate reverses imatinib resistance in patients with chronic myeloid leukemia.
1/2012DNA methylation-independent reversion of gemcitabine resistance by hydralazine in cervical cancer cells.
12/2011A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer. Preliminary results.
2/2011Transcriptional changes induced by epigenetic therapy with hydralazine and magnesium valproate in cervical carcinoma.
12/2006A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancer.
8/2006Global DNA hypermethylation-associated cancer chemotherapy resistance and its reversion with the demethylating agent hydralazine.
2/2006Hydralazine target: from blood vessels to the epigenome.
1/2006Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines.
5/2003Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy.

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Lucia Taja-Chayeb Research Topics

Disease

18Neoplasms (Cancer)
01/2022 - 05/2003
6Uterine Cervical Neoplasms (Cancer of the Cervix)
10/2014 - 07/2005
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
05/2016 - 01/2008
2Breast Neoplasms (Breast Cancer)
01/2012 - 12/2006
2Carcinoma (Carcinomatosis)
02/2011 - 05/2003
1Myocardial Ischemia (Ischemic Heart Diseases)
01/2022
1Stomach Neoplasms (Stomach Cancer)
01/2022
1Peptic Ulcer (Peptic Ulcers)
01/2022
1Parkinson Disease (Parkinson's Disease)
01/2022
1Hypercholesterolemia
01/2022
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
11/2021
1Lymphoma (Lymphomas)
09/2019
1Astrocytoma (Pilocytic Astrocytoma)
01/2018
1Colonic Neoplasms (Colon Cancer)
03/2017
1Virus Diseases (Viral Diseases)
11/2016
1Hepatitis C
11/2016
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2012
1Disease Progression
12/2011
1Infections
12/2011
1Li-Fraumeni Syndrome
12/2009
1Pancytopenia
01/2008
1Tachycardia (Tachyarrhythmias)
02/2006
1Headache (Headaches)
02/2006
1Dizziness (Lightheadedness)
02/2006
1Immune System Diseases (Immune Disorders)
02/2006
1Flushing
02/2006
1Hypotension (Low Blood Pressure)
02/2006
1Nausea
02/2006
1Glioma (Gliomas)
01/2006
1Head and Neck Neoplasms (Head and Neck Cancer)
01/2006
1Sarcoma (Soft Tissue Sarcoma)
01/2006
1Fibrosarcoma
01/2006
1Bronchiolo-Alveolar Adenocarcinoma (Adenocarcinoma, Bronchiolo Alveolar)
11/2005
1Lung Neoplasms (Lung Cancer)
11/2005
1Neutropenia
10/2005

Drug/Important Bio-Agent (IBA)

10Hydralazine (Apresoline)FDA LinkGeneric
10/2014 - 05/2003
7Valproic Acid (Depakote)FDA LinkGeneric
10/2014 - 07/2005
6DNA (Deoxyribonucleic Acid)IBA
01/2021 - 08/2003
5Pharmaceutical PreparationsIBA
01/2022 - 10/2005
4Histone Deacetylase InhibitorsIBA
10/2014 - 01/2006
4Histone Deacetylases (Histone Deacetylase)IBA
12/2011 - 07/2005
4Histones (Histone)IBA
02/2011 - 07/2005
3Fatty Acids (Saturated Fatty Acids)IBA
01/2022 - 03/2017
3Doxorubicin (Adriamycin)FDA LinkGeneric
01/2012 - 01/2006
2Ribavirin (Virazole)FDA LinkGeneric
09/2019 - 05/2015
2Orlistat (Xenical)FDA Link
01/2018 - 03/2017
2EnzymesIBA
01/2018 - 05/2015
2Proteins (Proteins, Gene)FDA Link
11/2016 - 02/2011
2LigandsIBA
11/2016 - 10/2006
2Cisplatin (Platino)FDA LinkGeneric
10/2014 - 12/2011
2Imatinib Mesylate (Gleevec)FDA Link
06/2012 - 10/2006
2Codon (Codons)IBA
12/2011 - 12/2009
2Biological ProductsIBA
12/2006 - 05/2003
1ApomorphineFDA Link
01/2022
1BenserazideIBA
01/2022
1Trimetazidine (Vastarel)IBA
01/2022
1Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2022
1Thalidomide (Thalomid)FDA Link
01/2022
1Pantoprazole (Protonix)FDA LinkGeneric
01/2022
1Arsenic Trioxide (Trisenox)FDA Link
01/2022
1Simvastatin (Zocor)FDA LinkGeneric
01/2022
1LipidsIBA
01/2022
1Rituximab (Mabthera)FDA Link
11/2021
1Cell-Free Nucleic AcidsIBA
01/2021
1Fatty Acid Synthases (Fatty Acid Synthase)IBA
01/2018
1Biomarkers (Surrogate Marker)IBA
01/2018
1AngiotensinogenIBA
01/2018
1lonidamineIBA
03/2017
1DiazooxonorleucineIBA
03/2017
1NK Cell Lectin-Like Receptor Subfamily KIBA
11/2016
1VaccinesIBA
11/2016
1Antiviral Agents (Antivirals)IBA
11/2016
1Folic Acid (Vitamin M)FDA LinkGeneric
05/2016
1Drug CombinationsIBA
10/2014
1Tyrosine Kinase InhibitorsIBA
06/2012
1GemcitabineFDA Link
01/2012
1Histone MethyltransferasesIBA
01/2012
1NucleosidesIBA
01/2012
1arginylarginine (Arg-Arg)IBA
12/2011
1Topotecan (Hycamtin)FDA LinkGeneric
12/2011
1Nonsense Codon (Nonsense Mutation)IBA
12/2009
1NucleotidesIBA
12/2009
12-mercaptopurineIBA
01/2008
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
12/2006
1Platelet-Derived Growth Factor alpha ReceptorIBA
10/2006
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2006
1Platelet-Derived Growth FactorIBA
10/2006
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
10/2006
1SaltsIBA
02/2006
1Antineoplastic Agents (Antineoplastics)IBA
01/2006
1ErbB Receptors (EGF Receptor)IBA
11/2005
1Gefitinib (Iressa)FDA Link
11/2005
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
11/2005
1Erlotinib Hydrochloride (CP 358,774)FDA Link
11/2005
1Phosphotransferases (Kinase)IBA
11/2005
1Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA
10/2005
1Irinotecan (Camptosar)FDA LinkGeneric
10/2005

Therapy/Procedure

10Therapeutics
01/2022 - 05/2003
4Drug Therapy (Chemotherapy)
10/2014 - 02/2006
1Combination Drug Therapy (Combination Chemotherapy)
12/2011